Retinol and Aging

As one of the most studied anti-aging compounds, retinol has shown strong positive effects to promote cell renewal, stimulate blood flow and collagen production. This helps to reduce fine lines and wrinkles, and improve skin tone. The basis of retinol’s anti-aging efficacy is the inhibition of the collagenase MMPs—thus preventing collagen degradation. Retinol was also reported to enhance gene expression for epidermal thickening and procollagen synthesis.

Adverse Effects of Conventional Retinol

Despite its anti-aging effects, retinol treatment causes skin irritations and inflammation such as burning, scaling, and dermatitis—limiting its acceptance by some patients. In addition to these, retinol is also highly unstable and susceptible to degradation via autoxidation (temperature) and photooxidation (UVB and UVA).

Mechanism of Action

As the gold-standard in anti-aging and rejuvenating skin care technology, SkinMTX® Intense RejuvorA Cream features the key active ingredient RejuvorA™—a unique, improved form of retinol complex using revolutionary encapsulation system to overcome the disadvantages of conventional retinol, while improving efficacy. Coupled with the benefits of ascorbyl glucoside and BioCalm10™, our cream provides impressive derma-renewal and collagen regenerative actions—while providing stellar protection against free radicals and wrinkle formation—making retinol rejuvenation safer, better, and more effective to prevent wrinkle formation, brighten the skin and retexturize skin complexion.


SkinMTX® Intense RejuvorA™

Triple Protection System SkinMTX® Intense RejuvorA Cream uses a triple protection system to stabilize retinol and minimize retinol exposure from oxidizing environment.


Fortified with BioCalm10™

BioCalm10™ is a botanically derived phytotherapy complex containing 10 different actives that helps the skin build resilience against environmental damage—imparting soothing relief to skin sensitivities, helping to calm irritation and promote healing. Key extracts include:

  • Green tea polyphenols7 with antioxidant and anti-inflammatory properties
  • Chamomile7 protects the skin from free-radical damage, accelerates tissue regeneration, helps tighten the pores and slows down the aging process
  • Resveratrol found in abundance in Japanese Knotweed8 improves blood flow and circulation—delivering nutrients and other materials necessary to keep the skin firm and elastic





TNF-α is a biomarker of inflammation/irritation. Activation of TNF-α by free radicals activates proteolytic degradation of the skin’s extracellular matrix and collagen fibrils. With ascorbyl glucoside acting as an antioxidant and inflammatory agent in SkinMTX® Intense RejuvorA Cream, activation of TNF-α can be reduced by half—making it safer for skin application.


A clinical study was performed on 24 female volunteers aged from 35 to 50 years

  • Test sample: retinol cream containing 3% RejuvorA™ (= 2,500 IU/g)
  • Applied once a day in the evening for 9 consecutive weeks
  • Results show impressive increase in skin elasticity, moisture, and collagen synthesis